Arbela Labs is revolutionizing biomanufacturing by combining our Pichia yeast system and proprietary integrated process technology. Our cutting-edge approach and market driven product formulations enables the production of high-quality proteins and other biomolecules at unprecedented scale and efficiency.
Pichia Yeast History
During the 1970s, P. pastoris (Pichia) yeast was isolated from French chestnut trees and California oak trees. It was discovered to have the unique ability to metabolize alcohols as both an energy source and for biomass and protein growth. Pichia is now recognized as being widely distributed in nature. In addition to methanol, it can also utilize other carbon sources, such as glycerol. In 1995, Pichia was reassigned as the sole representative of the genus Komagataella, becoming Komagataella pastoris
Pichia Yeast is incredibly safe
Arbela uses wild-type, non-GMO strains that comply with OECD (Organization for Economic Development) criteria for GILSP (Good Industrial Large-Scale Practice) microorganisms and meet the standards for safe production microorganisms. This strain has been fully characterized through genomic sequencing, with no antibiotic-resistant genes detected. There are no indications that P. pastoris is associated with animal or human illness. Extensive toxigenicity studies have concluded that native P. pastoris is nonpathogenic, does not produce toxins, and none of its proteins raise toxigenicity concerns or trigger allergic responses.
P. pastoris is recognized as GRAS (Generally Recognized As Safe) as an animal feed protein source, permitted in broiler feed at up to 10% of the total feed. It has been classified in Biosafety Level 1 (BSL-1) by the ATCC, signifying that Pichia is a well-characterized microorganism not known to cause disease in healthy human adults and poses minimal hazard to laboratory personnel and the environment. The safety of P. pastoris was assessed through intravenous injection of live yeast cells in mice to evaluate the immune response. Results indicated rapid elimination with no evidence of a cell-mediated immune response.
What is Pichia Yeast?
Pichia is a genus of yeast. Unlike common baker's or brewer's yeast, Pichia has unique characteristics that make it ideal for large-scale and low cost protein production without the need for land, water, fertilizer, pesticides/herbicides :
PIchia yeast is a wonderfood
Arbela’s Pichia yeast has been scrutinized through third-party certified testing, and it was found to contain within its nutritional composition: high protein content, full complement of amino acids, and rich in fiber, Vitamin B, and beta glucan.
Proven Safe
Non-Allergenic
Nontoxic
Non-Mutagenic
Non-Pathogenic
Supports Healthy Digestive Microflora:
Beta Glucan - Super Nutrient
One serving of Pichia has 5-10 times the amount of Beta Glucan shown to support optimal immune function.
Benefits Include:
Process Technology
Use of renewable feedstocks enables sustainable Pichia production
Pichia’s unique metabolism enables it to consume simple alcohols like Methanol or more complex polyols (Glycerol) that is used for cell growth, protein, fiber, and other nutrient production, and energy. The impact is profound as it enables protein and nutrition to be grown without any traditional agricultural inputs including land, water, fertilizers, pesticides or herbicides.
Coupling alcohol consuming Pichia yeast to integrated bioprocesses collapses cost structure while enabling massive scale. Glycerol feedstock is a byproduct of soap and biodiesel manufacturing and used in food and beverages as a sweetener and thickening agent. Methanol is produced at industrial scales and produced through a variety of routes. It can be made from biogas; gasified wastepaper, wood waste, animal waste and other sources or synthesized by combining captured CO2 and green hydrogen.
Arbela's Proprietary Pichia Process
Our integrated Pichia growth technology represents a breakthrough in biomanufacturing:
Scalability:
Enables mass production of proteins and biomolecules at economically viable scales
Efficiency:
Optimized for high-volume, cost-effective production
Versatility:
Capable of producing a wide range of compounds, from nutritional proteins to industrial enzymes
Combining the power of biology & process technology
Pichia Biology
Bioprocess Engineering
Novel Strains
Product Formulation
Pichia Biology
Proprietary Equipment
Proprietary Systems Integration
Our Approach: Green Alcohol Feed + Pichia Yeast - Protein
Green alcohol feedstock optionality…
Biodiesel Glycerol Waste
NO NET CARBON
Biomass, Sewage & Animal Waste, MSW
NO NET CARBON
Biomass, Sewage & Animal Waste, MSW
NO NET CARBON
Protein Production
Generally Regarded As Safe (GRAS)
Zero/Negative GHG
Separates protein production from land, water and other resources
Strong IP portfolio at all production and product stages
Strains
Bioprocess
Proprietary Equip. & Systems Integration
